Mauses Creek experiences siltation, organic enrichment, and low levels of dissolved oxygen.

In his book Trout Unlimited's Guide to Pennsylvania Limestone Streams, A. Joseph Armstrong describes Mauses Creek as "very similar to the upper portions of Kase and Sechler runs".

It flows south for some distance before turning northeast, running parallel to railroad tracks for some distance before crossing Pennsylvania Route 642 and making an abrupt turn east.

[1] It mainly flows in a north-south direction and joins Mauses Creek 1.20 miles (1.93 km) upstream of its mouth.

[5] Most of Mauses Creek is considered by the Pennsylvania Department of Environmental Protection to be impaired.

[7] The ten-year seven-day average minimum discharge of Mauses Creek is 63 gallons per minute.

However, the mouth of the creek and the upper reaches of some of its southernmost tributaries are over soil of the Clymer-Buchannnon-Norwich series.

[2] The elevation of the creek near its mouth is 482 inches (1,220 cm) above sea level.

[9] The creek is in the Riverside United States Geological Survey Topographical Quadrangle.

[10] A site known as the MW Manufacturing Company released pollution into Mauses Creek in the 20th century.

[2] Additionally, darters, dace, minnows, and bass inhabit the creek.