Pattonville consists of 27 square miles (70 km2) and it encompasses parts of the municipalities of Bridgeton, Maryland Heights, St. Ann, and a small portion of Creve Coeur.

Other portions are in unincorporated St. Louis County (between Creve Coeur and Overland).

The district has won several awards related to the academic success of its students.

[3] Pattonville spends over $14,000 per student and is ranked the most diverse school district in Missouri by Niche.

[4] Pattonville's neighboring districts include Hazelwood, Parkway, Ladue and Ritenour.