Continuing its course northwest and north, the highway passes a few businesses near the town center but its surroundings becomes more rural with some open fields and houses lining the road.

At Centerville, MS 363 exits the town limits of Mantachie, briefly curves towards the west, then resumes a northwest heading.

At the community of Ratliff, the highway curves to the west again and enters Lee County.

In the western part of the city, MS 363 is known as Mobile Street and passes through a residential neighborhood.

[4][5] A state highway, initially designated MS 371, connecting Mantachie with Saltillo was created in 1956.