The two-lane highway heads north through mostly wooded area of northern Monroe County.

The highway heads into Itawamba County, where it continues north through more wooded areas.

[2] North of this intersection, MS 371 makes a sweeping s-curve to reach an interchange with Interstate 22 (I-22) and U.S. Route 78 (US 78).

Continuing north, the highway passes in front of Mantachie High School.

As it exits the town, MS 371 crosses Twentymile Creek and heads through the census designated place of Kirkville.

North of Kirkville, MS 371 has a pair of quadrant interchanges with the Natchez Trace Parkway, each separated by about one-half mile (0.80 km), though either direction of the parkway is accessible from both interchanges.

MS 371 heads north, passing the town hall before traveling through unincorporated areas again.