At CO 5411, the road begins a series of turns through the forest.

It temporarily heads eastward at CO 5441, before turning south at CO 5345.

The route travels east again at CO 5450, around a small area of farmland.

MS 366 crosses over Casey Creek after intersecting CO 5481.

[4] It is legally defined in Mississippi Code § 65-3-3,[5] and is maintained by MDOT as part of the state highway system.