Monleale is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 100 kilometres (62 mi) east of Turin and about 30 kilometres (19 mi) east of Alessandria.

Monleale borders the following municipalities: Berzano di Tortona, Montegioco, Montemarzino, Sarezzano, Volpedo, and Volpeglino.

From 1412 it was enfeoffed to Perino Cameri and maintained by his descendants until 1727, who were succeeded by the Calcamuggi family of Alessandria.

Always a rival of the nearby Volpedo, in 1513 the Ghibelline Monleale attacked and destroyed the Guelph village on the other side of the river.

Monleale is home to the Volpedo Frutta cooperative, which brings together local producers and holds a number of trademarks related to the area's fruits.