M4 receptor-deficient mice exhibit increased locomotor simulation in response to D1 agonists, amphetamine and cocaine.

[8][9][10] Neurotransmission in the striatum influences extrapyramidal motor control, thus alterations in M4 activity may contribute to conditions such as Parkinson's disease.

[11][12][13] The M4 muscarinic receptor has been found to be a regulator of erythroid progenitor cell differentiation.

Inhibition of the M4 muscarinic receptor provides therapeutic benefits in myelodysplastic syndrome and anemia.

[14][15][16] This article incorporates text from the United States National Library of Medicine, which is in the public domain.