[5] Binding of the endogenous ligand acetylcholine to the M5 receptor triggers a number of cellular responses such as adenylate cyclase inhibition, phosphoinositide degradation, and potassium channel modulation.

Muscarinic receptors mediate many of the effects of acetylcholine in the central and peripheral nervous system.

The clinical implications of this receptor have not been fully explored; however, stimulation of this receptor is known to effectively decrease cyclic AMP levels and downregulate the activity of protein kinase A (PKA).

Some data may be obtained by observing which effects are common among semi-selective ligands (ex.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.