It is affiliated with the University of Central Florida College of Medicine[2] and is a member of the Nemours Children's Health, one of two freestanding hospitals in the system.

The hospital, a multi-year recipient of The Leapfrog Award for quality and safety,[3] provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[4][5] throughout Central Florida and beyond.

Adversaries of the project were concerned with the fact that two children's hospitals already existed in the Orlando region and another one would duplicate services and drive prices up.

Nemours then started an aggressive advertising campaign talking about wanting to bring a nationally recognized children's hospital to the Orlando region.

[10] Construction of the hospital began on February 25, 2009, and was managed by the architectural firm Skanska[11][12] and designed by a collaboration of Stanley Beaman, Sears Atlanta Perkins, Will Boston.