NYEE provides medical care for the diagnosis and treatment of ENT (ear, nose and throat) conditions affecting adults and children.

Some of the areas treated include chronic sinusitis, nasal obstructions, ear infections, nasal polyps, nosebleeds, deviated septum, hearing and balance disorders, thyroid and parathyroid conditions, head and neck tumor surgery, sleep issues, salivary gland disorders, and congenital deformities of the ear.

[5] In 2008, The Ear Institute at NYEE opened and continues to provide care for a wide range of hearing and balance disorders in children and adults.

The Ear Institute at NYEE was the first facility in New York to offer patients comprehensive, coordinated care in otologic services in a single location.

[6][7][8][9][10][11][12][13] Faculty and researchers in the Department of Ophthalmology advance the field of ophthalmology through basic, translational, and clinical research for a wide range of conditions focused on ocular imaging, advanced treatments, new surgical devices, and genetics and genomics of eye disease.

[7][8][9] Faculty at the Department of Otolaryngology at NYEE is engaged in translational research, clinical trials, and cross-departmental collaborations to develop new treatments and cures for conditions and diseases of the ears, nose, and throat.

Subspecialties include otology-neurotology, rhinology, facial plastics, head and neck surgery, laryngology, pediatrics, and sleep.

Founded on August 14, 1820,[2] the first Infirmary was located at 45 Chatham Street (which is now 83 Park Row), across from City Hall and near the Five Points neighborhood.

[15][16] On April 21, 1821, the first bylaws and rules and regulations were drawn up, and a Board of Directors, called "The Society of the New York Eye Infirmary," was formed.

Early supporters of the Infirmary included prominent New Yorkers such as Colonel William Few – who became the first President of the Infirmary Board from 1821 to 1828, Philip Hone, Benjamin Strong and David Hosack – the founder of Bellevue Hospital, who contributed funds and helped raise money for the fledgling clinic.

[18] Delafield and Rodgers opened the New York Eye Infirmary on August 14, 1820 at 45 Chatham Street (which is now 83 Park Row), across from City Hall and near the Five Points neighborhood.