Nicaragua competed at the 2016 Summer Olympics in Rio de Janeiro, Brazil, from 5 to 21 August 2016.

Nicaragua Olympic Committee (Spanish: Comité Olímpico Nicaragüense) sent the nation's smallest delegation to the Games since 2004.

[2] Majority of Nicaraguan athletes made their Olympic debut in Rio de Janeiro, except for butterfly swimmer Dalia Torrez Zamora, who attended her third Games as the oldest (aged 26) and most experienced competitor.

Meanwhile, air pistol shooter Rafael Lacayo, the youngest of the team (aged 17), led the delegation as the nation's flag bearer in the opening ceremony.

[7][8] Nicaragua has received an invitation from the Tripartite Commission to send Scarleth Mercado in the women's featherweight category (53 kg) to the Olympics.