North Fort Myers is an unincorporated area and census-designated place (CDP) in Lee County, Florida, United States.

It is part of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area.

It is bordered to the west by the city of Cape Coral and to the north by Charlotte County.

Interstate 75 runs through North Fort Myers, with access from Exit 143 (Florida State Road 78).

U.S. Route 41 (North Tamiami Trail) passes through the center of North Fort Myers, leading southeast across the Caloosahatchee Bridge into the center of Fort Myers and northwest 24 miles (39 km) to Port Charlotte.