Whiskey Creek is a census-designated place (CDP) in Lee County, Florida, United States.

It is part of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area.

[5] It is bordered to the north by the city of Fort Myers, the Lee county seat.

To the west it is bordered by the Caloosahatchee River and by a small tributary, Whiskey Creek, for which the community is named.

To the west across Whiskey Creek is the CDP of McGregor, while to the south is Cypress Lake and to the east are Villas, Pine Manor, and a southern extension of Fort Myers.