Odalengo Grande (Audalengh Grand in Piedmontese) is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 35 kilometres (22 mi) east of Turin and about 40 kilometres (25 mi) northwest of Alessandria.

Odalengo Grande borders the following municipalities: Cerrina Monferrato, Murisengo, Odalengo Piccolo, Robella, Verrua Savoia, Villadeati, and Villamiroglio.

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