Ozzano Monferrato is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 50 kilometres (31 mi) east of Turin and about 30 kilometres (19 mi) northwest of Alessandria.

Ozzano Monferrato borders the following municipalities: Casale Monferrato, Cella Monte, Cereseto, Pontestura, Rosignano Monferrato, Sala Monferrato, San Giorgio Monferrato, and Treville.

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