The route heads to the southeast, paralleling US 11 through forestry until the intersection with Jeffers Road, where it turns away from US 11 and enters fields.

The route makes several curves to the southeast and east, crossing through several large fields and industries.

The route keeps turning to the southeast, re-entering the deep woods and passing a large pond near West Lenox.

[3] After crossing from East Lenox, PA 106 continues southeastward through fields and soon into a region of residences.

The two designations become concurrent, paralleling the alignment of the Milford and Owego Turnpike Road through West Clifford.

The route continues further, passing through a lumber yard, where it turns southward and further southeastward into the community of Finch Hill.

[3] After leaving the golf course behind, PA 106 makes a gradual turn to the southeast at Crystal Lake Road.

At that intersection, the PA 106 designation terminates while Salem Avenue continues as SR 1019 through Carbondale.

[7] On December 3, 1971, the American Association of State Highway Officials approved the elimination of the US 106 designation.

The remainder of the route was removed from concurrencies with US 11 between south of New Milford and Kingsley and US 6 between Carbondale and Indian Orchard.