The right-hander won eight singles and seven doubles titles on the ATP World Tour and made the quarterfinals at the 2012 Wimbledon Championships.

He won his first career title in Munich defeating Mikhail Youzhny, thereby becoming the first German player to win the event since Michael Stich in 1994.

Kohlschreiber started 2008 by reaching the quarterfinals of the tournament in Doha and winning his second career title in Auckland, where he defeated Juan Carlos Ferrero in the final.

He reached the final of the Gerry Weber Open in Halle, Germany, eventually falling to the four-time champion Roger Federer 3–6, 4–6.

The German reached the second round at the Australian Open where he defeated Sam Querrey, before losing to Fabrice Santoro in five sets.

In the BNP Paribas Open in Indian Wells, Kohlschreiber beat Nicolás Lapentti 6–2, 3–6, 6–3 before being defeated by Fernando Verdasco in the fourth round.

He returned to action in San Jose seeing off local boy Rajeev Ram in three sets and crushing Dudi Sela, only losing two games.

Kohlschreiber got back to winning ways at the BNP Paribas Open in Indian Wells as he had a bye then beat fellow German Philipp Petzschner in straight sets.

He then went to the Heineken Open in Auckland where he won against Carlos Berlocq 2–6, 6–3, 6–1, and 6–4, 3–6, 6–2 against Marcel Granollers before falling to the top seed David Ferrer, 3–6, 7–6, 3–6, in the quarterfinals.

In the first round of the Davis Cup tie against Croatia, Kohlschreiber saved one match point in the second rubber against Ivan Dodig to win in five sets and to draw the score after day one.

In the fourth rubber, Marin Čilić was too strong for Kohlschreiber – he was defeated in straight sets to give the tie a 2–2.

On the way to the title, he overcame Cedrik-Marcel Stebe, Alexandr Dolgopolov, Lleyton Hewitt and Gaël Monfils.

Less than two weeks following his defeat of Nadal, Kohlschreiber beat Tommy Haas, Malek Jaziri and then Lukáš Rosol in straight sets 6–2, 6–3, 7–6 in the third round of Wimbledon Championships.

Kohlschreiber then advanced to the quarterfinals of a major for the first time by defeating Brian Baker,[11] but was thwarted by Jo-Wilfried Tsonga 7–6, 4–6, 7–6, 6–2.

Kohlschreiber defeated Paul-Henri Mathieu in the first round of the Australian Open in straight sets for his first win of the season, before bowing out to Bernard Tomic in a tightly contested four-set match, 7–6, 4–6, 6–7, 6–7.

He was very dominant against Japanese Go Soeda to begin the French Open, losing only three games, but could not get past Pablo Andújar despite winning sets three and four.

Kohlschreiber then took part in Kitzbühel, defeating two top-30 players in Fabio Fognini and Dominic Thiem in the quarter- and semifinals, respectively.

The US Open saw his best grand slam performance of the year, defeating countryman Alexander Zverev in five sets, and then taking down Lukas Rosol with a score of 7–6, 6–2, 6–2.

Kohlschreiber then represented Germany in their Davis Cup team against the Czech Republic where he beat both Lukáš Rosol and Tomáš Berdych.

In February, Kohlschreiber played in the Dubai Tennis Championships where he beat eighth seed Gilles Muller in straight sets.

In the quarterfinals, Kohlschreiber who was aiming to win his 400th match on tour lost in three tight sets to eventual champion and world No.

Later that month at the Miami Open, as the 26th seed, Kohlschreiber won his second-round match in three sets against young American Taylor Fritz.

[13] He lost in the first round at the 2021 Wimbledon Championships to Denis Shapovalov, where he also used his protected ranking, after a hard-fought five setter lasting more than 3+1⁄2 hours.

Unable to defend his third round showing at Roland Garros from the year before, and despite qualifying at Indian Wells earlier in the season, he fell out of the top 150 on 6 June 2022.

He has strong groundstrokes on both wings which are equally as solid and is often able to wrong-foot opponents due to his quick follow-through, forcing them to commit early.

Complementing his strong baseline play, as an all-court player, Kohlschreiber is also a proficient volleyer and uses variety to construct points.