Prallethrin

It is marketed as a mosquito repellent by Godrej as "GoodKnight Silver Power", SC Johnson as "All Out" and Southern Labs as "Quit Mozz" in India.

It is the main ingredient in the consumer product "Hot Shot Ant & Roach Plus Germ Killer" spray.

The liquid is drawn up through a porous clay carbon wick by capillary action then vaporized with a heater.

Type II pyrethroids contain an alpha-cyano moiety and produce a syndrome in rats that includes pawing, burrowing, salivation, and coarse tremors leading to choreoathetosis.

The adverse outcome pathway (AOP) shared by pyrethroids involves the ability to interact with voltage-gated sodium channels (VGSCs) in the central and peripheral nervous system, leading to changes in neuron firing, and ultimately neurotoxicity.

In the subchronic rat neurotoxicity study, a higher arousal rate was observed in animals at the highest dose tested.

Thyroid effects were observed in rats and consisted of increases in the number of small follicles and follicular cell hypertrophy and hyperplasia.

Maternal effects in the studies included tremors, salivation, exaggerated reflexes, and chromorhinorrhea (the discharge of a pigmented secretion from the nose).

Other gene mutation, chromosomal aberration, and unscheduled DNA synthesis (UDS) studies were negative; therefore, there is no concern for genotoxicity.

The weight of evidence from the available guideline, non-guideline, mechanism of action, and pharmacokinetics studies supports characterizing the toxicological profile of pyrethroids, including prallethrin, as being rapid in onset and associated with acute, peak exposures.

A mosquito repellent vaporizer