Penn Presbyterian Medical Center, sometimes called Presby, is a hospital located in the University City section of West Philadelphia.

The Reverend Dr. Ephraim D. Saunders, a Presbyterian minister, dedicated the land in memory of his son Courtland, who was shot and killed in service on September 21, 1862, in a battle during the Civil War.

This commitment was renewed in 1952, when the trustees of the Hospital voted against moving to the more affluent suburbs, choosing to remain in West Philadelphia.

The Hospital remained independent but formally affiliated with Penn in 1965, changing its name to Presbyterian–University of Pennsylvania Medical Center.

The Scheie Eye Institute (ranked #17 in ophthalmology by U.S. News & World Report) has received national attention for expertise and service.

[7] Penn Medicine University City, located on the hospital's campus at 3737 Market Street, is an affiliated outpatient facility and advanced treatment center specializing in musculoskeletal care.