Isidro Metapán, being the defending champions, kept the title as they won the final against Alianza on penalties.
The season begun on July 31 and concluded on December 19, 2010.
The top four teams by the end of the regular season took part of the playoffs.
Teams promoted from 2009–10 Segunda División Teams relegated to 2010–11 Segunda División Last updated: June 30, 2010
Luis Ángel Firpo A.D. Isidro Metapán Once Municipal