Regarding its structure, quinuclidine is unusual in that the methylene hydrogen atoms are eclipsed within each of the three ethylene linkages.

[4] Quinuclidine is a relatively strong organic base with pKa of the conjugate acid of 11.3.

Because of its compact structure, quinuclidine binds to trimethylborane more tightly than does triethylamine.

[7] Quinuclidine is structurally related to DABCO, in which the other bridgehead is also nitrogen, and to tropane, which has a slightly different carbon frame.

[7] Aceclidine, a simple quinuclidine derivative, is a drug used for treatment of glaucoma.