[7] This gene is expressed in the central and peripheral nervous system, spleen, mandibular maxillary processes, and blood islands.

Rev-Erbβ plays a major role in the conduction of inductive signals to aid in controlling differentiating neurons.

[5] The name Rev-Erbβ was coined a few months later in a paper by Eva Enmark, Tommi Kainu, Markku Tapio Pelto-Huikko, and Jan Ǻke Gustafsson where they isolated Rev-Erb alpha cDNA in a rat brain.

In mammals, the NR1D2 (nuclear receptor subfamily 1 group D member 2) gene encodes the protein Rev-Erbβ.

[9] Comparison of the human NR1D2 sequence with other species indicates a high level of conservation across animals, with 472 discovered orthologs, including in mice, chickens, lizards, and zebrafish.

[11] Much like Rev-Erbα, Rev-Erbβ can bind to two classes of DNA response elements via its DBD, which contains two C4-type zinc fingers.

This protein also helps maintain clock and metabolic gene regulation and protects system functioning when Rev-Erbα is missing.

For example: Rev-Erbβ plays a role in blocking the trans-activation of retinoic acid-related orphan receptor-α (RORα).

[16] Rev-Erbβ is also a circadian regulated gene; its mRNA displays rhythmic expression in vivo and in serum-synchronized cell cultures.

Hence, the Rev-Erbα receptor detects heme and thereby coordinates the cellular clock, glucose homeostasis, and energy metabolism.

Originally Rev-Erbβ was thought to be functionally redundant of Rev-Erbα but recent findings prove that there are subtle differences.