As such, its criteria for defining individual secondary structures are more complex than those of DSSP.
The STRIDE energy function contains a hydrogen-bond term containing a Lennard-Jones-like 8-6 distance-dependent potential and two angular dependence factors reflecting the planarity of the optimized hydrogen bond geometry.
Although DSSP is the older method and continues to be the most commonly used, the original STRIDE definition reported it to give a more satisfactory structural assignment in at least 70% of cases.
[1] Using a sliding-window method to smooth variations in assignment of single terminal residues, current implementations of STRIDE and DSSP are reported to agree in up to 95.4% of cases.
[2] Both STRIDE and DSSP, among other common secondary structure assignment methods, are believed to underpredict pi helices.