Saint Lucia competed at the 2016 Summer Olympics in Rio de Janeiro, Brazil, from 5 to 21 August 2016.

Saint Lucia Olympic Committee sent a team of five athletes, two men and three women, to compete only in sailing, swimming, and track and field at the Games, matching the nation's roster size with Sydney 2000 and beating the record by a single athlete set in both Beijing 2008 and London 2012.

[2] Two Saint Lucian athletes were awarded universality places to compete in their respective sporting events, while the rest of the team qualified directly for the Games on merit.

High jumper and Pan American Games champion Levern Spencer spearheaded the Saint Lucian delegation for the third consecutive time, as the oldest and most experienced competitor (aged 32) and the nation's flag bearer in the opening ceremony.

[1] Other notable athletes on the roster featured Spencer's teammate Jeanelle Scheper and ex-NFL running back turned track sprinter Jahvid Best.