The Salcha seismic zone is a fault line in the Interior region of Alaska, United States, generally located to the east of Fairbanks.

The fault runs for 65 km (40 mi) from the northern edge of the Alaska Range across the Tanana Valley to the southern end of the Yukon–Tanana Uplands and is parallel to the Fairbanks and Minto Seismic Zones located further west.

[3] Stresses created by these features results in clockwise rotation of the crust underlying the Tanana Valley including Fairbanks, North Pole, and Salcha.

[1][5] The combination of the Salcha, Fairbanks, and Minto seismic zones generate thousands of small earthquakes each year.

A series of mounds on the Salcha River floodplain may have been created by tectonic processes associated with the seismic zone.