Sale is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 90 kilometres (56 mi) east of Turin and about 15 kilometres (9 mi) northeast of Alessandria.

Sale borders the following municipalities: Alessandria, Alluvioni Piovera, Castelnuovo Scrivia, Guazzora, Isola Sant'Antonio, Tortona.

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