He has also played for the Los Angeles Rams, Kansas City Chiefs, Baltimore Ravens, and Green Bay Packers.

[1][2] He became the all-time leading receiver in the history of Lee County with 133 catches for 2,997 yards and 36 touchdowns during his career.

[4] In addition to football, Watkins ran track & field for the Wolfpack, where he was one of the state's top performers in the sprinting events.

[7] Regarded as a five-star recruit by Rivals.com, he was rated the third-best wide receiver prospect in the nation, behind only George Farmer and Trey Metoyer.

[11] Even though he didn't take part in spring practice, Watkins made an immediate impact for Clemson in his freshman season in 2011.

[13] He also broke 11 school freshman records seven games into the season, including total all-purpose yards previously held by C. J.

[13] Watkins was an Associated Press first-team All-American, becoming only the fourth ever true freshman to do so, joining Herschel Walker, Marshall Faulk and Adrian Peterson.

[29] Watkins finished his season setting a new Bills rookie record in both receptions (65) and receiving yards (982).

"[32] On October 27, 2015, frustrated with his social media followers for leaving angry comments about him missing three games due to injury, Watkins took to his Instagram and lashed out at critical fans.

[34] Watkins followed up, with a clarification posted on Twitter stating, "Message wasn't for fans (but) for whomever have a problem with athletes being injured.

[35] Playing on an injured ankle that had kept him out of a Friday practice, Watkins had a career-high 168 receiving yards on eight catches with one touchdown in a Week 9 33–17 victory over the Dolphins.

Watkins had a screw inserted in his foot, and the Bills medical staff was hopeful that would be ready for training camp.

[45] Watkins recorded his first touchdown of the season with 106 yards against the San Francisco 49ers in Week 3 with a stunning catch for the Rams 41–39 victory.

[46] In Week 9, Watkins caught a season-long 67-yard reception from Jared Goff that resulted in a touchdown as part of the 51–17 blowout win by the Rams over the New York Giants.

[49][50] In the 2018 season opener, he recorded three receptions for 21 yards in his Chiefs debut against the Los Angeles Chargers.

[56] On September 8, 2019, Watkins recorded nine receptions for a career-high 198 yards and three touchdowns against the Jacksonville Jaguars as the Chiefs won 40–26 in Week 1.

[59] In Super Bowl LIV against the 49ers, Watkins caught five passes for 98 yards, including a 38-yard catch on what proved to be the game-winning drive, during the 31–20 win.

[60] In Week 16 against the Atlanta Falcons, Watkins threw an interception to safety Keanu Neal on a trick play during the 17–14 win.

[63][64] His best game of the season came in Week 1 when he had four receptions for 96 yards in a 33–27 overtime loss to the Las Vegas Raiders.

[79] In September 2017, Lindsey Thiry of the Los Angeles Times reported that Watkins believes the Earth is flat.

[80] In a May 2020 interview with Bleacher Report, Watkins opened up about his struggles with mental health and addiction throughout his career, in addition to his spiritual beliefs.