San Giorgio Monferrato (in Piedmontese San Giòrs Monfrà) is a comune of the Province of Alessandria in the Italian region Piedmont.

The territory of this small rural commune of the Monferrato Casalese extends over an area of 7.1 square kilometres (2.7 sq mi).

Its population of 1,293[3] is concentrated in the village of San Giorgio (Saint George).

The communal coat of arms pictures the saint killing the dragon.

San Giorgio clusters around a medieval castle on a low hill southwest of Casale Monferrato, which dominates the road from Casale to Asti.