San Sebastiano Curone (Piedmontese: San Bastiau Curou ) is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 110 kilometres (68 mi) southeast of Turin and about 40 kilometres (25 mi) southeast of Alessandria, at the confluence of the Curone and Museglia streams.

San Sebastiano Curone borders the municipalities of Brignano-Frascata, Dernice, Gremiasco, and Montacuto.

Part of the commune of Fabbrica Curone it was under the dominations of the Malaspina and Fieschi from Genoa.

In the 16th century, under the Doria, it became an important market centre for salt, fish and cereals.

This article on a location in the Province of Alessandria is a stub.