South Carolina Highway 133 (SC 133) is a 20.540-mile (33.056 km) state highway in Pickens County, South Carolina, connecting Clemson and western Pickens County with access to the Blue Ridge Mountains and the SC 11 (Cherokee Foothills Scenic Highway).

The route of SC 133 travels generally in a south–north direction, beginning at an intersection with U.S.

The highway skirts rural areas west of Central before entering the community of Six Mile.

[2] Prior to streetscaping activities in downtown Clemson, the route used to include College Avenue and terminated at SC 93 at the front of the campus of Clemson University.

[citation needed] The entire route is in Pickens County.