SC 414 begins at an intersection with U.S. Route 276 (US 276; Geer Highway) south of Marietta, within Greenville County.

It travels to the north-northeast and curves to the northeast and crosses Bull Creek.

On the southeastern edge of the university is an intersection with the northern terminus of SC 253 (Mountain View Road).

It curves to the east and passes Ebenezer Cemetery just before heading to the southeast.

It curves back to the east just before meeting its eastern terminus, an intersection with SC 14.