The business loop's western terminus was at the MacArthur Maze interchange.

From there, it ran concurrently with State Route 17 (present-day Interstate 880) along Cypress Street, later the Cypress Freeway, to Broadway in Downtown Oakland.

then headed north on Broadway and then east on Grand Avenue towards the end of Lake Merritt.

The business route then turned south on El Embarcadaro and then east on Lakeshore Avenue before rejoining US 50 at MacArthur Boulevard, later the MacArthur Freeway.

It has been activated and deactivated on multiple occasions and concealed signs have been permanently installed so the route can be reactivated as needed.

The route follows a local road called Mormon Emigrant Trail from Sly Park up a ridge to eventually connect with California State Route 88 over Carson Pass, using a small portion of California State Route 89 over Luther Pass to reconnect with US 50 near South Lake Tahoe.

The former route followed present-day portions of Sly Park Road, Mormon Emigrant Trail in its entirety, and portions of SR 88 and SR 89.

It was in use when from 2009 to 2018 when Interstate 580 was partially built and terminated at the Fairview Drive exit.

was a business route of US 50 in the U.S. state of Nevada, and carried the unsigned designation of SR 530.

It was removed as part of a mileage swap between the Nevada Department of Transportation and Carson City public works in 2010.

was a 292-mile (470 km) alternate route of US 50 in Nevada and Utah.

It existed from the 1953 to the 1976 and followed the original routing of US 50 from Ely, Nevada to Moark Junction, Utah (roughly 11 miles [18 km] south-southeast of Provo in what is what is now the east edge of Spanish Fork), via Salt Lake City.

The designation was deleted in the 1970s, about the time that US 50 was again rerouted (to its current routing) in 1976.

was a 17.1-mile (27.5 km) temporary route of US 50 in Utah, departing the alignment of what is now U.S. Route 6 (UT 6) at the site of the former community of Kyune (roughly 3.7 miles [6.0 km] southeast of Colton) along what is now called Emma Park Road and returning to US 6 in southern Castle Gate via what is now U.S. Route 191 (US 191).

The first road built between Helper and Soldier Summit exited the Price River Canyon along modern US 191 near Castle Gate and returned to the current alignment of UT 6 via Emma Park Road to bypass a narrow, meandering portion of the canyon.

Once announced this road would be used for the Midland Trail (precursor to US 6) a shorter, more direct route was proposed that remained in Price Canyon for the entire ascent.

The road is occasionally as a detour when US 6 through Price Canyon is closed.

[16] In 1958, part of the bypass route in Illinois was rerouted north to connect to Cahokia.

[17] On June 25, 1974, AASHTO approved the decommissioning of US 50 Bypass in order for US 50 to avoid St. Louis while also connecting to East St.

[19] US 50 Alternate was then decommissioned in 1962 after the US 50 expressway bypassed downtown Lawrenceville.

was an alternate route of US 50 in the U.S. states of Ohio and West Virginia.

was a temporary route of US 50 in the District of Columbia and the U.S. state of Maryland.

The highway runs 6.88 miles (11.07 km) from US 50 on the northwest side of Salisbury to US 13 and US 50 on the east side of Salisbury in central Wicomico County.

US 50 Business west of MD 349 is a mid-1950s upgrade of the original highway entering Salisbury from the northwest.

East of MD 346, US 50 Business is part of the relocation of US 50 between Salisbury and Berlin completed in the mid-1960s.

US 50 Business was designated when the US 50 portion of the Salisbury Bypass was completed in 2002.