[8] Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins.

Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells.

[9] TUBA1A is believed to play a role in neuronal migration by regulating microtubule dynamics, enabling the rapid formation and disassembly of polymers, which allows for the extension and retraction of processes necessary for nucleokinesis.

Embryonic day 16.5 sections showed strong labeling in the telencephalon, diencephalon, mesencephalon, developing cerebellum, brainstem, spinal cord, and dorsal root ganglia.

Treatment is symptomatic; anti-convulsive drugs for seizure activity, g-button gastrostomy to feed the child, physical therapy for muscle disorders.