[citation needed] As an antiparasitic, tiabendazole is able to control roundworms (such as those causing strongyloidiasis),[7] hookworms, and other helminth species which infect wild animals, livestock, and humans.

It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels.

[12] Tiabendazole works by inhibition of the mitochondrial, helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone.

Effects on humans from use as a drug include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine occur.

[17] A number of derivatives of tiabendazole are also pharmaceutical drugs, including albendazole, cambendazole, fenbendazole, oxfendazole, mebendazole, and flubendazole.