Thiophosphate

They are the basis of antisense therapy, e.g., the drugs fomivirsen (Vitravene), oblimersen, alicaforsen, and mipomersen (Kynamro).

Monothiophosphate esters are biochemical reagents used in the study of transcription,[4] substitution interference assays.

Some have attracted interest as components in fast ion conductors for use in solid state batteries.

The binary thiophosphates do not exhibit the extensive diversity of the analogous oxyanions but contain similar structural features, for example P is 4 coordinate, P−S−P links form and there are P−P bonds.

One difference is that ions may include polysulfide fragments of 2 or more S atoms whereas in the P−O anions there is only the reactive −O−O−, peroxo, unit.