The system was declassified as a tropical cyclone the following day, a remnant circulation later moved over Louisiana and Mississippi, producing heavy rainfall and causing flooding.

[4] By late August 9, the low reached the southeastern Gulf of Mexico, and the National Hurricane Center (NHC) noted a medium chance for tropical or subtropical development, due to an anticipated decrease in wind shear.

[5] The convection gradually increased and became better organized,[6] and a hurricane hunters flight late on August 10 confirmed the development of Tropical Depression Five about 120 miles (190 km) west of Fort Myers, Florida.

[7] Early on August 11, the convection diminished significantly due to the entrainment of dry air and vertical wind shear from a nearby upper-level low.

[15] Early on August 16, the low reached the Gulf of Mexico,[16] and a hurricane hunters flight reported a weak circulation and convection that was disorganized and disassociated.

Upper-level conditions remained only marginally favorable, although the NHC noted that "only a small increase in organization would result in the formation of a tropical depression.

[20] Once in the Gulf of Mexico, the developing system threatened the area affected by the Deepwater Horizon oil spill; this prompted BP to stop operations temporarily in constructing a relief well.

In Panama City Beach, Florida, one man was hospitalized,[25] and on Anna Maria Island, two elderly people died after being swept away by rip currents; the deaths were believed to have been fatigue-induced heart attacks, and not drowning.

[27] While the depression moved through the region, it dropped heavy rainfall of up to 8 in (20 cm) around the New Orleans area, flooding streets as well as entering one apartment complex.

[33] Further inland, the remnants interacted with a stationary cold front over central Tennessee, causing $22 million in damage after heavy rainfall affected bridges, roads, and properties.