[4] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg, who also developed the troponin T assay.

[5] The reference range for the high sensitivity troponin T is a normal < 14 ng/L, borderline of 14-52 ng/L, and elevated of >52 ng/L.

[6] The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration.

Increased troponin T levels after an episode of chest pain indicates myocardial infarction.

[9] In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack).