U.S. Route 227 (US 227) was a U.S. Highway that was commissioned in Kentucky from 1928 to 1972, and ran from Richmond to Carrollton.

The route headed north to the Kentucky River at Fort Boonesborough.

In Paris, the highway intersected US 27 and US 60 before running concurrently with US 460 west through Centreville and across Kentucky Route 922 into Georgetown.

There, the highway briefly ran concurrently with US 62, and intersected US 25, before both US 460 and US 25 split off and US 227 continued northwest through Stamping Ground.

[1] The current designation of the road is: The list below includes most intersections of US 227 before its 1972 decommission.