U.S. Route 412 (US 412) enters the state of Missouri from Arkansas near Cardwell.

The highway leaves the state into Tennessee concurrent with I-155 near Caruthersville.

US 412 enters the state from Arkansas after crossing the St. Francis River.

The highway enters into the small town of Cardwell before turning to the north, passing through Senath.

In Kennett, the highway turns back to the east, concurrent with Route 84.