Vitamin K antagonist

For example, it is needed to carboxylate specific glutamic acid residues on prothrombin.

However, in the case of the second generation superwarfarins intended to kill warfarin-resistant rodents, the time of vitamin K administration may need to be prolonged to months, in order to combat the long residence time of the poison.

They have been largely superseded by second-generation anticoagulants because warfarin-resistant rodents have become more common.

[6] Anisindione, fluindione, and phenindione are oral anticoagulant medicines with actions similar to warfarin.

However, the indandiones are generally more toxic than warfarin, with hypersensitivity reactions involving many organs and sometimes resulting in death.

Warning label on a tube of "brown rat" poison laid on a dike of the Scheldt river in Steendorp, Belgium. The tube contains bromadiolone , a second-generation ( superwarfarin ) anticoagulant. The label in Dutch states, in part: Contains an anticoagulant with prolonged activity. Antidote Vitamin K1.
Vitamin K 2 (menaquinone). In menaquinone the side chain is composed of a varying number of isoprenoid residues.
Vitamin K is used to produce coagulation factors. VKAs interfere with the recycling of Vitamin K epoxide into Vitamin K (step 4 to 1).