1DEV, 1MK2, 4BKW9372230597ENSG00000157077ENSMUSG00000034557O95405n/aNM_004799NM_007323NM_007324NM_183300NM_001347163NM_001384118NP_004790NP_015563n/aZinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.

[5] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling.

It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.

[6] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.