ZNF839

[5] Zinc finger protein 839 is speculated to play a role in humoral immune response to cancer as a renal carcinoma antigen (NY-REN-50).

[11] It has been found that there is high expression of ZNF839 in the testis, specifically the seminiferous tubules, after RNA-sequencing analysis of various human tissues.

[11][12][13] The high expression of the human ZNF839 gene in the testis may be due to its C2H2-zinc finger role in transcriptional regulation during spermatogenesis.

[15] The high expression of ZNF839 in the gyri of the cerebrum may be due to the regulatory involvement of zinc finger proteins in neurodevelopment.

[16] The human zinc finger protein 839, isoform 1, has 927 amino acids and holds a molecular weight of 87.5 kDa.

[19][20] The pat4 nuclear localization signal was conserved among all strict orthologs of the human zinc finger protein 839.

[23] Thus, TP53 and zinc finger protein 839 may interact to transcribe genes necessary for DNA damage response or tumor suppression.

Thus, zinc finger protein may significantly play a role in tumor suppression and regulation of cellular pathways such as cell division.

Zinc finger protein 839 is found in the following vertebrates: mammals, birds, reptiles, amphibians, and fish.

Zinc finger protein 839 conceptual translation with annotations depicting important domains, signals, and conserved sites.
ZNF839 Expression in Various Regions of the Brain. The bright red areas represent high ZNF839 expression. The following gyri have high ZNF839 expression and high z-scores: short insular gyri, postcentral gyrus, fusiform gyrus, and parolfactory gyri. These images were annotated with the help of Allen Brain Atlas.
Zinc Finger Protein 839 Tertiary Structure. This structure was elucidated and annotated with the help of AlphaFold and iCN3D.
Zinc finger protein 839 schematic illustration showing phosphorylation sites (phos), sumoylation sites (sumo), negative charge cluster (NCC), positive charge cluster (PCC), C2H2 zinc finger, conserved alpha-helix region, and nuclear localization signal (NLS).
ZNF839 evolution rate graph