The regiment is named for the city of Perugia and part of the Italian Army's infantry arm.

The regiment was reformed in August 1941 for service in World War II and assigned to the 151st Infantry Division "Perugia".

The division resisted invading German forces and Albanian partisans and tried to reach the coast in the hope to be able to embark for Italy.

Both regiments consisted of three battalions, which each fielded four fusilier companies and one machine gun section.

[2][3] During World War I the Brigade "Perugia" fought on the Italian front: in July 1915 at Lucinico near Gorizia and then in November and December during the Fourth Battle of the Isonzo on the slopes of Monte San Michele on the Karst plateau.

In June 1916 the brigade was transferred as reinforcements to the Sette Comuni plateau, where the Austro-Hungarian Army had unleashed the Battle of Asiago on 15 May.

For their conduct during the war the brigade's two regiments were each awarded a Silver Medal of Military Valor.

The remnants of the 130th Infantry Regiment "Perugia" fought their way to the harbour of Vlorë and set up a defensive perimeter, which managed to withstand the German attacks until 20 September 1943.

The remnants of the 129th Infantry Regiment "Perugia", together with the division's command, reached the harbour of Sarandë, where the Germans besieged the Italians.