The regiment is named for the city of Catanzaro and part of the Italian Army's infantry arm.

In May 1940 regiment was reformed in preparation for Italy's entry into World War II.

The regiment was assigned to the 64th Infantry Division "Catanzaro", which was transferred to Italian Libya.

Both regiments consisted of three battalions, which each fielded four fusilier companies and one machine gun section.

In August 1916 the brigade was back on Karst plateau for the Sixth Battle of the Isonzo fighting on the slopes of Monte San Michele and for the summit of Nad Logem.

On 28 December 1916 the King of Italy Victor Emmanuel III awarded the 141st Infantry Regiment Italy's highest military honor, the Gold Medal of Military Valor, for the regiment's conduct during the Sixth Battle of the Isonzo.

[5] After its arrival in Libya the regiment consisted of a command, a command company, three fusilier battalions, a support weapons battery equipped with 65/17 infantry support guns, and a mortar company equipped with 81mm Mod.

[2][5][7] On 10 June 1940 Italy entered World War II and the Catanzaro division assembled at Acroma to guard the approach to Tobruk.

There the division was split in smaller units, which manned positions between in the Buqbuq sector between Sallum and Sidi Barrani.