The 1979–80 Iowa State Cyclones men's basketball team represented Iowa State University during the 1979–80 NCAA Division I men's basketball season.
The Cyclones were coached by Lynn Nance, who was in his fourth and final season with the Cyclones.
They played their home games at Hilton Coliseum in Ames, Iowa.
Assistants Rick Samuels and Reggie Warford took over for the remainder of the season.
The Cyclones lost in the first round of the Big Eight tournament to Kansas State, falling 101–87.