2-Amino-3-carboxymuconic semialdehyde[1][2] is an intermediate in the metabolism of tryptophan in the tryptophan-niacin catabolic pathway.

Quinolinate is a neurotoxin formed nonenzymatically from 2-amino-3-carboxymuconic semialdehyde in mammalian tissues.

2-Amino-3-carboxymuconic semialdehyde is enzymatically converted to 2-aminomuconate via 2-aminomuconic semialdehyde.

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