The 2000 Belarusian Premier League was the tenth season of top-tier football in Belarus.

Svisloch-Krovlya Osipovichi and Molodechno, who finished 15th and 16th respectively, relegated to the First League.

They were replaced by 1999 First League winners Kommunalnik Slonim and runners-up Vedrich-97 Rechytsa, who previously played in top league as Vedrich Rechytsa.

The championship runners-up BATE Borisov, 1999–2000 Cup winners Belshina Bobruisk and UEFA Fair Play ranking winners Shakhtyor Soligorsk qualified for UEFA Cup.

Due to Premiere League reduction from 16 to 14 teams starting with next season, three lowest placed teams were relegated: Lida, Torpedo-Kadino Mogilev and Kommunalnik Slonim.