The 2021 Abierto Zapopan was a professional tennis tournament played on outdoor hard courts.

It was the 2nd edition of the tournament and part of the 2021 WTA Tour.

Originally scheduled for 16–21 March 2020 in Guadalajara, Mexico and was part of the 125K series during the 2020 tennis season, but was cancelled due to the COVID-19 pandemic due to local restrictions, and the suspension of play on the WTA tour.

[1][2] It took place in Guadalajara, Mexico from 8 to 13 March 2021 and it was a part of the WTA 250 tournaments, offering a total of $235,238 in prize money.

[3][4] *per team The following players received a wildcard into the singles main draw: The following players received entry using a protected ranking into the main draw: The following players qualified into the singles main draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates into the doubles main draw: