The 2021 Ladies Open Lausanne was a women's tennis tournament played on outdoor clay courts.

It was the 28th edition of the Ladies Open Lausanne, and part of the 250 category of the 2021 WTA Tour.

It took place at Tennis Club Stade-Lausanne in Lausanne, Switzerland, from 12 through 18 July 2021.

[1] This was Zidanšek's maiden WTA Tour singles title.

The following players received wildcards into the main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: