The 2021 Courmayeur Ladies Open was a women's tennis tournament played on indoor hard courts.

[1] It was the first edition of the Courmayeur Ladies Open, and part of the WTA 250 series of the 2021 WTA Tour.

It was held at the Courmayeur Sport Center in Courmayeur, Italy, from 25 until 31 October, 2021.

[2] This was Vekić's third WTA singles title, and first since 2017.

The following players received wildcards into the main draw: The following players received entry using a protected ranking into the main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: